Timing is one of the highest-leverage habits in B2B follow-up. The best-known evidence comes from inbound leads: the 2007 Lead Response Management study (InsideSales.com and MIT) found the odds of qualifying a lead dropped 21 times when a company called at 30 minutes instead of 5, and Harvard Business Review's 2011 study of 1.25 million leads found firms that responded within an hour were nearly seven times as likely to qualify them as firms that waited an hour longer.
The 4-hour window is the warm-thread version of that idea. When a prospect replies or starts re-reading your email, they're thinking about the problem right then. A reply that lands the same day meets them there. One that lands next week starts over.